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                  Alzheimer's: Is a bad diet to blame?

Suzanne de la Monte’s rats were disoriented and confused. Navigating their way around a circular water maze – a typical memory test – they forgot where they were and couldn’t remember how to locate the hidden, submerged safety platform.

A closer look at their brains uncovered devastating damage. Areas associated with memory were studded with bright pink plaques, like rocks in a climbing wall, while many neurons, full to bursting point with a toxic protein, were collapsing and crumbling, teetering on the brink of death.

Such changes are the hallmarks of Alzheimer’s disease, yet they arose in surprising circumstances . De la Monte, a neuropathologist at Brown University in Rhode Island, US, had treated the rats with a diabetes drug that interfered with how their brains responded to insulin. The hormone is most famous for controlling blood sugar levels – poor sensitivity to insulin is typically associated with type 2 diabetes – but it also plays a key role in brain signalling. And results such as de la Monte’s have led some researchers to wonder whether Alzheimer’s may sometimes be a version of diabetes that hits the brain – de la Monte even renamed it "type 3 diabetes" - and others concur. 

If they're right, the implications are deeply troubling. Since sugary, high kilojoule foods are known to impair our body's response to insulin, we may be poisoning our brains every time we feast on burgers, fries and a soft drink.


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